The special effects of VK2
Blood clotting. Vitamin K2 is essential for the carboxylation of glutamate residues in certain proteins, to give carboxyglutamate. This modification allows the protein to bind calcium, an essential event in the blood clotting cascade.
Atherosclerotic. This may be due in part to the geranylgeranyl side chain of vitamin K2 which is thought to inhibit the mevalonate pathway, thus preventing the prenylation of growth factors required for osteoclast activation in much the same way as nitrogen-containing bisphosphonates.
Bone health. Vitamin K2 (menatetrenone) can prevent fractures and sustains lumbar bone mineral density in osteoporosis.
Osteoporosis. Vitamin K2, combined with vitamin D and calcium, has been used primarily as treatment or prevention of osteoporosis.
Leucocythemia. Vitamin K2 and its derivatives induce apoptosis in leukemia cells and enhance the effef aof all-trans retinoic acid.
Blood disorders. Vitamin K2 (menadione) may improve a group of blood disorders known as myelodysplastic syndromes (MDS).
Vitamin K2 is more effective than vitamin K1 with respect to osteoclastogenesis likewise hypocholesterolemic effects and the ability to slow atherosclerotic progression have only been observed with vitamin K2.
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